guide to optical coherence tomography interpretation

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology. Comparative diagnostic performance of volumetric laser endomicroscopy and confocal laser endomicroscopy in the detection of dysplasia associated with Barrett’s esophagus. Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions. Ophthalmic OCT reaches $1 billion per year. Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.

Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography. High-speed optical frequency-domain imaging. Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. time domain optical coherence tomography. Sensitivity advantage of swept source and Fourier domain optical coherence tomography. In vivo endoscopic optical biopsy with optical coherence tomography. Scanning single-mode fiber optic catheter–endoscope for optical coherence tomography. High-speed phase- and group-delay scanning with a grating-based phase control delay line.

Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography. High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al 2O 3 laser source. OCT elastography: imaging microscopic deformation and strain of tissue. Characterization of fluid flow velocity by optical Doppler tomography. Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography.

Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging. Eye-length measurement by interferometry with partially coherent light. Optical frequency domain reflectometry in single-mode fiber. Optical coherence-domain reflectometry: a new optical evaluation technique. Finally, image artefacts and limitations that commonly arise and future advances and opportunities are considered. Image processing, display and interpretation, which are all critical for effective biomedical imaging, are discussed in the context of specific applications. The signal processing methods and algorithms that make OCT exquisitely sensitive to reflections, as weak as just a few photons, and reveal functional information in addition to structure are examined. Although OCT has been used for imaging inanimate objects, the discussion focuses on biological and medical imaging. In this Primer, the principles underpinning the different instrument configurations that are tailored to distinct imaging applications are described and the origin of signal, based on light scattering and propagation, is explained. OCT can be configured as a conventional microscope, an ophthalmic scanner or endoscopes and small-diameter catheters for accessing internal biological organs. Optical coherence tomography (OCT) is a non-contact method for imaging the topological and internal microstructure of samples in three dimensions.

Guide to optical coherence tomography interpretation